Non-furnace boilers can improve the efficiency of industrial once-through boilers. However, temperature non-uniformity occurs in the economizer connected vertically to the boiler. Heat transfer performance is degraded by temperature non-uniformity. To solve this problem, a corbel was installed on the side wall of the economizer, and a baffle was installed on the transition duct. Consequently, although the thermal efficiency of the boiler was improved, significant temperature non-uniformity was still observed in the area upstream of the economizer. To address this issue, this study designed a turning guide vane (TGV) at the economizer inlet using computational fluid dynamics (CFD). First, CFD was performed for a case without a guide vane and a case with an existing baffle installed. By analyzing the streamlines obtained using CFD, two TGV designs were proposed. In the first design, guide vanes were installed along the desired streamline, and the concept of the existing TGV was followed. In the second design, an attempt was made to minimize the pressure drop by arranging guide vanes at the inlet. Both designs reduced the standard deviation of temperature by more than 30% and improved the volume goodness factor by 25%.