The main objective of this research was to create two different configurations of a flat-plate solar air heater, namely, Conventional-Case A and Modified-Case B, and develop a three-dimensional computational fluid dynamics (CFD) model using ANSYS R15.0. The purpose of the CFD model was to simulate the heat transfer behavior of the proposed solar air heaters under unsteady conditions. The RNG k-ε turbulence model was employed for this CFD study. The experiments were conducted on sunny days, under the same conditions as the Egyptian climate. The results of the experiments show that the simulated CFD model and the measured outlet airflow temperatures, relative humidity, and velocities of the two tested solar air heaters were compared. The developed model made very satisfactory predictions. Moreover, the deviations between the average CFD outlet air temperatures and the experimental results were 7% and 7.8% for Case B and Case A, respectively. The CFD-simulated average relative humidity was reduced by 31.6% when using Case B compared with Case A, and it was reduced by 28.8% when comparing the experimental data to Case B. Additionally, the average CFD thermal efficiencies obtained for Case B and Case A were 28.7% and 21.6%, respectively, while the average experimental thermal efficiencies for the cases were 26.4% and 18.2%, respectively. The proposed model can be used to design and simulate other solar air heater designs.