Essential Oils of Two Portuguese Endemic Species of Lavandula as a Source of Antifungal and Antibacterial Agents

Joana Domingues; Manuela Goulão; Fernanda Delgado; José Carlos Gonçalves; Joana Gonçalves; Cristina Santos Pintado

LAPSE

Living Archive for Process Systems Engineering

LAPSE:2023.35241

Published Article

LAPSE:2023.35241

Essential Oils of Two Portuguese Endemic Species of Lavandula as a Source of Antifungal and Antibacterial Agents

Joana Domingues, Manuela Goulão, Fernanda Delgado, José Carlos Gonçalves, Joana Gonçalves, Cristina Santos Pintado

April 28, 2023

Chemical investigations of L. stoechas subsp. luisieri and L. pedunculata essential oils were analyzed by GC-MS, and the antimicrobial activity was performed against bacteria and fungi isolated from food sources. The cytotoxicity of the essential oil was performed in NHDF cells using the MTT method. According to the results, the main compounds of L. stoechas subsp. luisieri essential oil were trans-α-necrodyl acetate (40.2%), lavandulyl acetate (11%), and trans-α-necrodol (10.4%), while fenchone (50.5%) and camphor (30.0%) in L. pedunculata essential oil. The antifungal activity of essential oils was confirmed with MIC values ranging from 1.2 to 18.7 µL/mL; for bacteria, it ranged from 4.7 to 149.3 µL/mL. Both the Lavandula species tested showed low or equal MIC and MBC/MFC values for L. stoechas subsp. luisieri essential oil, revealing greater efficacy in antimicrobial activity. The L. stoechas subsp. luisieri essential oil revealed cytotoxic effects (30 ± 2% of cell viability) in NHDF cells at all concentrations tested.

Record ID

LAPSE:2023.35241

Keywords

antimicrobial activity, chemical profile, cytotoxicity, L. pedunculata, L. stoechas subsp. luisieri

Subject

Biosystems

Suggested Citation

Domingues J, Goulão M, Delgado F, Gonçalves JC, Gonçalves J, Pintado CS. Essential Oils of Two Portuguese Endemic Species of Lavandula as a Source of Antifungal and Antibacterial Agents. (2023). LAPSE:2023.35241

Author Affiliations

Domingues J: Plant Biotechnology Centre of Beira Interior (CBPBI), 6001-909 Castelo Branco, Portugal; Health Sciences Research Centre (CICS), University of Beira Interior, 6200-506 Covilhã, Portugal [ORCID]
Goulão M: Polytechnic Institute of Castelo Branco-School of Agriculture (IPCB-ESA), 6001-909 Castelo Branco, Portugal
Delgado F: Polytechnic Institute of Castelo Branco-School of Agriculture (IPCB-ESA), 6001-909 Castelo Branco, Portugal; Research Centre for Natural Resources, Environment and Society, Polytechnic Institute of Castelo Branco (CERNAS-IPCB), 6001-909 Castelo Branco, Po [ORCID]
Gonçalves JC: Polytechnic Institute of Castelo Branco-School of Agriculture (IPCB-ESA), 6001-909 Castelo Branco, Portugal; Research Centre for Natural Resources, Environment and Society, Polytechnic Institute of Castelo Branco (CERNAS-IPCB), 6001-909 Castelo Branco, Po [ORCID]
Gonçalves J: Health Sciences Research Centre (CICS), University of Beira Interior, 6200-506 Covilhã, Portugal
Pintado CS: Polytechnic Institute of Castelo Branco-School of Agriculture (IPCB-ESA), 6001-909 Castelo Branco, Portugal; Research Centre for Natural Resources, Environment and Society, Polytechnic Institute of Castelo Branco (CERNAS-IPCB), 6001-909 Castelo Branco, Po [ORCID]

Journal Name

Processes

Volume

11

Issue

4

First Page

1165

Year

2023

Publication Date

2023-04-10