Subsea jumpers connecting the underwater wellhead and nearby manifold commonly undergo flow-induced vibration (FIV) due to the spatially frequent alteration in the flow direction, velocity, pressure and phase volume fraction of the oil−gas two-phase flow, potentially leading to fatigue damage. This paper reports the numerical results of the FIV of a reversed U-shaped jumper excited by gas−liquid two-phase flow, which evolves from the initial slug flow with a fixed gas−liquid ratio of 1:2 when transporting through the jumper. The FIV response and flow pattern evolution are examined with a gas flow rate of Qg = 4−12 kg/s and a liquid flow rate of QL = 96−288 kg/s. When the gas−liquid flow passes through the jumper, the flow regime subsequently presents the slug flow, bubble flow, churn flow and imperfect annular flow. The out-of-plane response frequency coincides with the pressure fluctuation frequency for the four connecting bends, suggesting the fluid−structure interaction (FSI). Nevertheless, the vibration displacement is limited with the maximum value less than 0.0014D (where D is the jumper diameter) in the present considered flow rate range.