Geotechnical seismic isolation (GSI) consists of an innovative technique to mitigate the effects of earthquakes based on interposing a superficial soil layer to filter the seismic energy from the soil to the structure. This approach is particularly applied in developing countries due to low-cost applications. In order to account the uncertainties, the presented paper aimed to develop fragility curves of 3D configurations performed by numerical finite element models. The mail goal is to assess and discuss the potentialities of GSI as a mitigation technique for several configurations. Opensees PL has been applied to perform the numerical analyses and to realistically reproduce the behaviour of GSI.