Jetted conductor setting depth is crucial for deep-water drilling. This paper presents an innovative method for determining the shallow soil resistance strength recovery factor based on the field data of Equatorial Guinea bay. It shows that the soil strength recovery factor of Equatorial Guinea bay is lower than that of the Gulf of Mexico. The conductor setting depth calculation referring to other place will have a high risk of wellhead sinking. According to the newly established designing charts, the conductor setting depth was recommended for the S1 well. Each preferred set-up period requires a specific setting depth. If the chosen set-up period is 2 days, the expected setting depth of a 36″ conductor should be 250 ft (76.2 m) and, similarly, 295 ft (89.9 m) for a 30″ conductor. The relationship between set-up period and surface conductor setting depth is established as well. Wellhead landed load appears to be the crucial factor for determining the conductor setting depth. The rationality of the newly developed shallow soil strength recovery model for the Equatorial Guinea deep-water block was also confirmed by the field data.