The aim of this work is to propose a unified (generalized) closure of the chemical source term in the context of Large Eddy Simulation able to cover all the regimes of turbulent premixed combustion. Turbulence/combustion scale interaction is firstly analyzed: a new perspective to look at commonly accepted combustion diagrams is provided based on the evidence that actual turbulent flames can experience locally several combustion regimes although global non-dimensional numbers would locate such flames in a single specific operating point of the standard combustion diagram. The deliverable is a LES subgrid scale model for turbulent premixed flames named Localized Turbulent Scales Model (LTSM). This is founded on the estimation of the local reacting volume fraction of a computational cell that is related to the local turbulent and laminar flame speeds and to the local flame thickness.