Uneven air distribution in chamber dryers is a common and serious technological challenge. A study using CFD (Computer Fluid Dynamics) simulation, supported by measurements in a heat pump chamber dryer, confirmed irregular airflows. Performing simulations with modified settings and additional chamber modifications enabled the airflows to be visualized and optimized. It was shown that a modification of the chamber where a rotating disc had been used had a positive effect on the uniform distribution of air flows in the drying chamber. The modification significantly improves the energy balance of the beef drying process. Optimization of the process resulted in obtaining a high quality final product-beef jerky. This investigation proves that appropriate drying process control and introduced modifications enable high product quality and a safe level of water activity without the preservatives supplementation.