Different methods to achieve zero-energy and low carbon on the scale of a building are shown by most of the research works. Despite this, the recommendations generally offered by researchers do not always correspond to the realities found during the construction of new buildings in a determined region. Therefore, a standard may not be valid in all climate regions of the world. Being aware of this fact, a study was carried out to analyse the design of new buildings respecting the “zero-energy and low carbon emission” concept in tropical climatic regions when they are compared with a base case of temperate regions. To reach this objective, the comparison between real and simulated data from the different buildings studied was developed. The results showed that the renovation of existing residential buildings allows for reducing up to 35% of energy demand and a great quantity of CO2 emissions in both climate types. Despite this, the investment rate linked to the construction of zero-energy buildings in tropical zones is 12 times lower than in temperate zones and the payback was double. In particular, this effect can be related to the efficiency of photovoltaic panels, which is estimated to be, at least, 34% higher in tropical zones than temperate zones. Finally, this study highlights the interest and methodology to implement zero-energy buildings in tropical regions.