Lining is often used as the last line of defense in deep large section chamber. Under the asymmetric load, it is easy to damage, resulting in the overall repair of the chamber. Aiming at this problem, taking the pump house in Wanfu Coal Mine under construction in China as an engineering example, we analyzed the asymmetric failure of pump house lining caused by construction disturbance, established the lining mechanical model and quantitative evaluation indexes, such as bending moment change rate, bending moment balance rate, displacement change rate and displacement balance rate, studied the influence mechanism of asymmetrical coefficient, section size and lining thickness on the mechanical behavior of lining, and proposed the control measures of deep large section chamber with the core of “strengthening asymmetric support, reducing section size and improving lining strength”. The field monitoring shows that the asymmetric deformation of the pump house is effectively controlled, and the maximum displacement is only 7.3 mm, which ensures the long-term stability of the chamber.