Currently, international business and society are on the eve of large-scale changes. The study aims to develop a methodological approach to assess the energy flexibility of multinational corporations in the context of the structural transformation management of renewable energy production. The methodology of this study is based on a comprehensive approach, which includes the methodology of the United States Agency for International Development (USAID), diagnostics of the level of development and energy flexibility of multinational corporations, regression analysis and scenario modeling. In particular, scenario analysis of renewable energy development in countries of the Commonwealth of Independent States (CIS) and economic analysis of projects for the development of corporate renewable energy industry were carried out. The results showed that the Russian renewable energy business is flexible enough for changes; however, at the same time, changes are needed in the national legislation, the basics of work, the national energy market; the conditions should be formed for the development of this business, a green tariff on a market basis should be formed, etc. The scientific contribution of this study is the proposed indicator in the form of the Multinational Corporation Energy Flexibility Index. It provides an opportunity to diagnose the agility of multinational corporations’ development, taking into account changes in their production structure. The developments obtained in the course of the work can be applied for studies related to assessing the flexibility of national energy systems, as well as in the practice of managing multinational corporations operating in the field of renewable energy.