Globally, the heat sector has a major share in energy consumption and carbon emission footprint. To provide reliable mitigation options for space heating, domestic hot water, industrial process heat and biomass for cooking for the energy transition time frame up to the year 2050, energy system modeling relies on a comprehensive and detailed heat demand database in high spatial resolution, which is not available. This study overcomes this hurdle and provides a global heat demand database for the mentioned heat demand types and in a resolution of 145 mesoscale regions up to the year 2050 based on the current heat demand and detailed elaboration of parameters influencing the future heat demand. Additionally, heat demand profiles for 145 mesoscale regions are provided. This research finds the total global heat demand will increase from about 45,400 TWhth in 2012 up to about 56,600 TWhth in 2050. The efficiency measures in buildings lead to a peak of space heating demand in around 2035, strong growth in standards of living leads to a steady rise of domestic hot water consumption, and a positive trend for the worldwide economic development induces a growing demand for industrial process heat, counterbalanced by the efficiency gain in already industrialised countries. For the case of biomass for cooking, a phase-out path until 2050 is presented. Literature research revealed a lack of consensus on future heat demand. This research intends to facilitate a more differentiated discussion on heat demand projections.