Electricity Distributions Networks (DNs) are changing from a once passive to an active electric power system element. This change, driven by several European Commission Directives and Regulations in the energy sector prompts the proliferated integration of new network elements, which can actively participate in network operations if adequately utilized. This paper addresses the possibility of using these active DN elements for optimization of a time-discrete network operation in terms of minimization of power losses while ensuring other operational constraints (i.e., voltage profiles and line currents). The active elements considered within the proposed optimization procedure are distributed generation units, capable of reactive power provision; remotely controlled switches for changing the network configuration; and an on-load tap changer-equipped substation, supplying the network. The proposed procedure was tested on a model of an actual medium voltage DN. The results showed that simultaneous consideration of these active elements could reduce power losses at a considered point of operation while keeping the voltage profiles within the permitted interval. Furthermore, by performing a series of consecutive optimization procedures at a given time interval, an optimization of network operations for extended periods (e.g., days, months, or years) could also be achieved.