China intends to develop its renewable energy sector in order to cut down on its pollution levels. Concentrated solar power (CSP) technologies are expected to play a key role in this agenda. This study evaluated the technical and economic performance of a 100 MW solar tower CSP in Tibet, China, under different heat transfer fluids (HTF), i.e., Salt (60% NaNO3 40% KNO3) or HTF A, and Salt (46.5% LiF 11.5% NaF 42% KF) or HTF B under two different power cycles, namely supercritical CO2 and Rankine. Results from the study suggest that the Rankine power cycle with HTF A and B recorded capacity factors (CF) of 39% and 40.3%, respectively. The sCO2 power cycle also recorded CFs of 41% and 39.4% for HTF A and HTF B, respectively. A total of 359 GWh of energy was generated by the sCO2 system with HTF B, whereas the sCO2 system with HTF A generated a total of 345 GWh in the first year. The Rankine system with HTF A generated a total of 341 GWh, while the system with B as its HTF produced a total of 353 GWh of electricity in year one. Electricity to grid mainly occurred between 10:00 a.m. to 8:00 p.m. throughout the year. According to the results, the highest levelized cost of energy (LCOE) (real) of 0.1668 USD/kWh was recorded under the Rankine cycle with HTF A. The lowest LCOE (real) of 0.1586 USD/kWh was obtained under the sCO2 cycle with HTF B. In general, all scenarios were economically viable at the study area; however, the sCO2 proved to be more economically feasible according to the simulated results.