For commercial applications, the durability and economy of the fuel cell hybrid system have become obstacles to be overcome, which are not only affected by the performance of core materials and components, but also closely related to the energy management strategy (EMS). This paper takes the 7.9 t fuel cell logistics vehicle as the research object, and designed the EMS from two levels of qualitative and quantitative analysis, which are the composite fuzzy control strategy optimized by genetic algorithm and Pontryagin’s minimum principle (PMP) optimized by objective function, respectively. The cost function was constructed and used as the optimization objective to prolong the life of the power system as much as possible on the premise of ensuring the fuel economy. The results indicate that the optimized PMP showed a comprehensive optimal performance, the hydrogen consumption was 3.481 kg/100 km, and the cost was 13.042 $/h. The major contribution lies in that this paper presents a method to evaluate the effect of different strategies on vehicle performance including fuel economy and durability of the fuel cell and battery. The comparison between the two totally different strategies helps to find a better and effective solution to reduce the lifetime cost.