LAPSE:2023.3227
Published Article
LAPSE:2023.3227
Lipocalin, Resistin and Gut Microbiota-Derived Propionate Could Be Used to Predict Metabolic Bariatric Surgery Selected Outcomes
February 22, 2023
Abstract
Many patients with clinically severe obesity (CSO) need to undergo bariatric surgery, with possible side effects, so individualized predictive methods are required. Adipocytokines and gut/intestinal microbiota-derived metabolites could be predictive biomarkers of metabolic success post- surgery, but the knowledge in this field is undefined. The objective of this work was to determine whether adipocytokines and microbiota-derived metabolites can be used to predict the metabolic improvement post- surgery in women with CSO. We analyzed circulating levels of some cytokines and some microbiota-derived metabolites at baseline and 12 months post-surgery from 44 women with CSO and 21 women with normal weight. Results showed that glucose, insulin, glycosylated hemoglobin A1c (HbA1c), low-density lipoprotein (LDL-C), and triglycerides levels were decreased post-surgery, while high density lipoprotein increased. Twelve months later, leptin, resistin, lipocalin, PAI-1, TNF-α, and IL-1β levels were lower than baseline, meanwhile adiponectin, IL-8, and IL-10 levels were increased. Moreover, baseline lipocalin levels were associated with HbA1c reduction post-surgery; meanwhile baseline resistin was related to postoperative HOMA2 (insulin resistance) and baseline propionate was associated with LDL-C decrease. To conclude, the detection of lipocalin, resistin, and propionate levels may be used to predict the metabolic success following bariatric surgery, although new knowledge is needed.
Many patients with clinically severe obesity (CSO) need to undergo bariatric surgery, with possible side effects, so individualized predictive methods are required. Adipocytokines and gut/intestinal microbiota-derived metabolites could be predictive biomarkers of metabolic success post- surgery, but the knowledge in this field is undefined. The objective of this work was to determine whether adipocytokines and microbiota-derived metabolites can be used to predict the metabolic improvement post- surgery in women with CSO. We analyzed circulating levels of some cytokines and some microbiota-derived metabolites at baseline and 12 months post-surgery from 44 women with CSO and 21 women with normal weight. Results showed that glucose, insulin, glycosylated hemoglobin A1c (HbA1c), low-density lipoprotein (LDL-C), and triglycerides levels were decreased post-surgery, while high density lipoprotein increased. Twelve months later, leptin, resistin, lipocalin, PAI-1, TNF-α, and IL-1β levels were lower than baseline, meanwhile adiponectin, IL-8, and IL-10 levels were increased. Moreover, baseline lipocalin levels were associated with HbA1c reduction post-surgery; meanwhile baseline resistin was related to postoperative HOMA2 (insulin resistance) and baseline propionate was associated with LDL-C decrease. To conclude, the detection of lipocalin, resistin, and propionate levels may be used to predict the metabolic success following bariatric surgery, although new knowledge is needed.
Record ID
Keywords
adipocytokines, bariatric surgery, biomarker, microbiota, obesity
Subject
Suggested Citation
Auguet T, Lopez-Dupla M, Ramos J, Bertran L, Riesco D, Aguilar C, Ardévol A, Pinent M, Sabench F, Del Castillo D, Richart C. Lipocalin, Resistin and Gut Microbiota-Derived Propionate Could Be Used to Predict Metabolic Bariatric Surgery Selected Outcomes. (2023). LAPSE:2023.3227
Author Affiliations
Auguet T: Internal Medicine Unit, Hospital Universitari Joan XXIII, 43007 Tarragona, Spain; GEMMAIR Research Group (AGAUR)-Medicina Aplicada, Department of Medicine and Surgery, Institut d’Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgil [ORCID]
Lopez-Dupla M: Internal Medicine Unit, Hospital Universitari Joan XXIII, 43007 Tarragona, Spain [ORCID]
Ramos J: Internal Medicine Unit, Hospital Universitari Joan XXIII, 43007 Tarragona, Spain
Bertran L: GEMMAIR Research Group (AGAUR)-Medicina Aplicada, Department of Medicine and Surgery, Institut d’Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili (URV), 43007 Tarragona, Spain [ORCID]
Riesco D: Internal Medicine Unit, Hospital Universitari Joan XXIII, 43007 Tarragona, Spain; GEMMAIR Research Group (AGAUR)-Medicina Aplicada, Department of Medicine and Surgery, Institut d’Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgil
Aguilar C: GEMMAIR Research Group (AGAUR)-Medicina Aplicada, Department of Medicine and Surgery, Institut d’Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili (URV), 43007 Tarragona, Spain
Ardévol A: MoBioFood Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43007 Tarragona, Spain [ORCID]
Pinent M: MoBioFood Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43007 Tarragona, Spain [ORCID]
Sabench F: GEMMAIR Research Group (AGAUR)-Medicina Aplicada, Department of Medicine and Surgery, Institut d’Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili (URV), 43007 Tarragona, Spain; Surgery Unit, Hospital Sant Joan de Reus, Departm
Del Castillo D: GEMMAIR Research Group (AGAUR)-Medicina Aplicada, Department of Medicine and Surgery, Institut d’Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili (URV), 43007 Tarragona, Spain; Surgery Unit, Hospital Sant Joan de Reus, Departm
Richart C: GEMMAIR Research Group (AGAUR)-Medicina Aplicada, Department of Medicine and Surgery, Institut d’Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili (URV), 43007 Tarragona, Spain
Lopez-Dupla M: Internal Medicine Unit, Hospital Universitari Joan XXIII, 43007 Tarragona, Spain [ORCID]
Ramos J: Internal Medicine Unit, Hospital Universitari Joan XXIII, 43007 Tarragona, Spain
Bertran L: GEMMAIR Research Group (AGAUR)-Medicina Aplicada, Department of Medicine and Surgery, Institut d’Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili (URV), 43007 Tarragona, Spain [ORCID]
Riesco D: Internal Medicine Unit, Hospital Universitari Joan XXIII, 43007 Tarragona, Spain; GEMMAIR Research Group (AGAUR)-Medicina Aplicada, Department of Medicine and Surgery, Institut d’Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgil
Aguilar C: GEMMAIR Research Group (AGAUR)-Medicina Aplicada, Department of Medicine and Surgery, Institut d’Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili (URV), 43007 Tarragona, Spain
Ardévol A: MoBioFood Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43007 Tarragona, Spain [ORCID]
Pinent M: MoBioFood Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43007 Tarragona, Spain [ORCID]
Sabench F: GEMMAIR Research Group (AGAUR)-Medicina Aplicada, Department of Medicine and Surgery, Institut d’Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili (URV), 43007 Tarragona, Spain; Surgery Unit, Hospital Sant Joan de Reus, Departm
Del Castillo D: GEMMAIR Research Group (AGAUR)-Medicina Aplicada, Department of Medicine and Surgery, Institut d’Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili (URV), 43007 Tarragona, Spain; Surgery Unit, Hospital Sant Joan de Reus, Departm
Richart C: GEMMAIR Research Group (AGAUR)-Medicina Aplicada, Department of Medicine and Surgery, Institut d’Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili (URV), 43007 Tarragona, Spain
Journal Name
Processes
Volume
10
Issue
1
First Page
143
Year
2022
Publication Date
2022-01-11
ISSN
2227-9717
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PII: pr10010143, Publication Type: Journal Article
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LAPSE:2023.3227
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https://doi.org/10.3390/pr10010143
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Feb 22, 2023
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