This paper deals with photovoltaic (PV) power plant modeling and its integration into the medium-voltage distribution network. Apart from solar cells, a simulation model includes a boost converter, voltage-oriented controller and LCL filter. The main emphasis is given to the comparison of two optimization methods—particle swarm optimization (PSO) and the Ziegler−Nichols (ZN) tuning method, approaches that are used for the parameters of Proportional-Integral (PI) controllers determination. A PI controller is commonly used because of its performance, but it is limited in its effectiveness if there is a change in the parameters of the system. In our case, the aforementioned change is caused by switching the feeders of the distribution network from an open-loop to a closed-loop arrangement. The simulation results have claimed the superiority of the PSO algorithm, while the classical ZN tuning method is acceptable in a limited area of operation.