This paper proposes a methodology aiming at determining the most influent working variables and geometrical parameters over the pressure drop and heat transfer during the condensation process of several refrigerant gases using heat exchangers with pipes mini channels technology. A multi-criteria decision making (MCDM) methodology was used; this MCDM includes a mathematical method called SIMUS (Sequential Interactive Modelling for Urban Systems) that was applied to the results of 2543 tests obtained by using a designed refrigeration rig in which five different refrigerants (R32, R134a, R290, R410A and R1234yf) and two different tube geometries were tested. This methodology allows us to reduce the computational cost compared to the use of neural networks or other model development systems. This research shows six variables out of 39 that better define simultaneously the minimum pressure drop, as well as the maximum heat transfer, saturation pressure fluid entering the condenser being the most important one. Another aim of this research was to highlight a new methodology based on operation research for their application to improve the heat transfer energy efficiency and reduce the CO2 footprint derived of the use of heat exchangers with minichannels.