A suspended open-type ceiling radiant cooling panel (CRCP) has been proposed recently. The main challenge is improving its cooling performance to overcome limitations for extensive use. Therefore, this study aims to optimize the design of CRCPs with curved and segmented structure to enhance heat transfer. A three-dimensional CFD model was developed to investigate the cooling capacity and heat transfer coefficient of the CRCPs installed inside a single enclosed room. Panel structure was determined based on four dependent parameters: the panel curvature width (L, m), the panel curvature radius (r, m), the void distance (d, m) between each panel or panel segment, and the panel coverage area (Ac, m2). The panel surface area (As, m2) and the ratio of panel curvature width to radius (L/r) were also examined. A total of 35 designs were compared under 7 different cooling load conditions, and 245 cases were carried out. The results show that the nominal cooling capacity and heat transfer coefficient rise with increasing curvature radius and decreasing curvature width. The void distance plays the most crucial role in influencing cooling performance. It is possible to simultaneously improve cooling performance, achieve uniform temperature distribution, and reduce the number of panels through structure optimization.