Prestack depth-migrated seismic data, having more accurate imaging position and amplitude fidelity than prestack time-migrated seismic data, are supposed to produce a higher quality reservoir prediction result by using depth-domain inversion. Some researchers have developed different methods of depth-domain seismic inversion. However, it has not been widely used in the industry probably because of two reasons: (1) it is a complex process to conduct depth-domain seismic inversion due to the nonstationary depth-domain seismic wavelet; and (2) time-domain seismic inversion is considered capable of solving the problem with less cost, both in regard to time and the economy. In this paper, we try to use the seismic waveform indicator inversion method in the depth domain. First, a forward model was built to demonstrate that seismic waveforms both in the time domain and the depth domain are highly correlated with lithologic associations. Second, a quantitative evaluation method of seismic data for reservoir prediction was proposed, which can help geophysicists estimate time-domain and depth-domain inversion effects before inversion. Finally, the seismic waveform indicator inversion method was implemented for presalt thin carbonate reservoir prediction in the Central Block at the eastern margin of the Pre-Caspian Basin. The depth-domain inversion result shows a relatively true structure and higher resolution validated by wells.