Wellbore instability is one of the most serious issues faced in the drilling process. During drilling operations, the cyclic loads applied on the fractured formation progressively modify the initial parameters (i.e., length and width) of the fractured formation, thus resulting into undesirable wellbore instability. In this paper, using a nonlinear finite element software (ABAQUS) as the numerical simulator, a poro-elasto-plastic model has been established which aimed at analyzing the influence of drill string vibration cyclic loads on the development of the wellbore natural fracture. The numerical results showed that the fracture width as a function of time profiles followed a sinusoidal behavior similar to the drill string vibration cyclic load profiles. For different cyclic load magnitudes with constant number of cyclic loads, the highest percentage increase of the fracture width after integration of cyclic loads was 64.77%. Interestingly, the fracture width increased with the fracture length in the near wellbore region while it globally decreased in the region far away from the wellbore. But for constant cyclic load magnitude with different number of cyclic loads, the biggest percentage increase of the fracture width after integration of cyclic loads was slightly lower representing 63.12% while the oscillating period of the fracture width increased with the number of cyclic loads. The parametric study revealed that the drill string vibration cyclic loads were relatively independent of the fracture length and the bottom hole pressure. However, the fracture width and the loss circulation rates were considerably impacted by the drill string vibration and the highest percentage increase of the loss circulation rate after integration of cyclic loads was 14.3%. This study provides an insight into the coupling of the fracture rock development and the continuous cyclic loads generated by drill string vibrations which is an aspect that has been rarely discussed in the literature.