Avoiding heat stress in cows is an important condition for animal productivity and the maintaining of animal health. For this, it is necessary to provide an optimal microclimate in cowsheds using systems of air cooling. The paper analyzes one of these systems—an air humidification−cooling system. The research was carried out in a semi-insulated box-type cowshed containing 244 places. The changes in temperature, relative humidity, and temperature humidity index (THI) were studied for the air coming from outside and for the air inside the cowshed. Considering the fact that the cows were in the cowshed most of the time (51.5%) under heat stress, the use of a cooling system is appropriate. It was established that a cooling system is capable of compensating for heat released by animals. It was determined that with an increase in air temperature the relative efficiency of a cooling system increases. An intensive constant air exchange provided using fan operation avoids an excessive growth of relative humidity in a cowshed. To reduce the consumption of electricity and water, the paper suggests regulation of both the power of the fans of the system and the water supply to the nozzles not using temperature but using THI. Theoretically, when THI is used to regulate the operation of the cooling system, the consumption of electrical energy is reduced by 17.8%, and the consumption of water is reduced by 43.2% when compared to the option when the temperature is used to regulate the operation of a cooling system.