The aim of this paper is to research the parameters that optimize the thermal performances of a horizontal single-duct Earth to Air Heat eXchanger (EAHX). In this analysis, the EAHX is intended to be installed in the city of Naples (Italy). The study is conducted by varying the most crucial parameters influencing the heat exchange between the air flowing in the duct and the ground. The effect of the geometrical characteristics of the duct (pipe length, diameter, burial depth), and the thermal and flow parameter of humid air (inlet temperature and velocity) has been studied in order to optimize the operation of this geothermal system. The results reveal that the thermal performance increases with length until the saturation distance is reached. Moreover, if the pipe is designed with smaller diameters and slower air flows, if other conditions remain equal, the outlet temperatures come closer to the ground temperature. The combination that optimizes the performance of the system, carried out by forcing the EAHX with the design conditions for cooling and heating, is: D = 0.1 m s−1; v = 1.5 m s−1; L = 50 m. This solution could also be extended to horizontal multi-tube EAHX systems.