Cryogenic air separation processes are widely used for the large-scale production of nitrogen and oxygen. The most widely used design for this process involves two distillation columns operating at different pressures. This work focuses on the selection of suitable cryogenic air separation process by evaluating seven alternative designs of the two-column air separation process based on detailed exergy analysis. The feed conditions (500 tons/h, and 50% relative humidity of air), product purities (99 mole% for both nitrogen and oxygen), and operational conditions (pressures of both distillation columns) are kept same in all designs. The two cryogenic distillation columns in each configuration are heat-integrated to eliminate the need for external utilities. Steady-state simulation results are used to calculate the exergy efficiency (%) of each equipment as well as its contribution toward the overall exergy destruction rate (kW) of the process. The results show that the compression section is a major source of exergy destruction, followed by the low-pressure column, and the multi-stream heat exchanger. A Petlyuk-like configuration, labeled as C1, provides the lowest exergy destruction rate.