There is a burden of adequate energy supply for meeting demand and reducing emission to avoid the average global temperature of above 2 °C of the pre-industrial era. Therefore, this study presents the exergoeconomic and environmental analysis of a proposed integrated multi-generation plant (IMP), with supplemental biomass-based syngas firing. An in-service gas turbine plant, fired by natural gas, was retrofitted with a gas turbine (GT), steam turbine (ST), organic Rankine cycle (ORC) for cooling and power production, a modified Kalina cycle (KC) for power production and cooling, and a vapour absorption system (VAB) for cooling. The overall network, energy efficiency, and exergy efficiency of the IMP were estimated at 183 MW, 61.50% and 44.22%, respectively. The specific emissions were estimated at 122.2, 0.222, and 3.0 × 10−7 kg/MWh for CO2, NOx, and CO, respectively. Similarly, the harmful fuel emission factor, and newly introduced sustainability indicators—exergo-thermal index (ETI) and exergetic utility exponent (EUE)—were obtained as 0.00067, 0.675, and 0.734, respectively. The LCC of $1.58 million was obtained, with a payback of 4 years, while the unit cost of energy was estimated at 0.0166 $/kWh. The exergoeconomic factor and the relative cost difference of the IMP were obtained as 50.37% and 162.38%, respectively. The optimum operating parameters obtained by a genetic algorithm gave the plant’s total cost rate of 125.83 $/hr and exergy efficiency of 39.50%. The proposed system had the potential to drive the current energy transition crisis caused by the COVID-19 pandemic shock in the energy sector.