LAPSE:2023.2678
Published Article
LAPSE:2023.2678
Health Effect of N-Nitroso Diethylamine in Treated Water on Gut Microbiota Using a Simulated Human Intestinal Microbiota System
February 21, 2023
Chlorination disinfection byproducts (CDBPs) can exert adverse human health effects. Many toxicology-based studies confirmed the health hazards of CDBPs, but little research has been done on gut microbiome. We explored the effect of CDBPs on intestinal microbiota in the Simulator of the Human Intestinal Microbial Ecosystem (SHIME). The results showed that CDBPs slightly inhibited the production of short-chain fatty acids, and the abundance of Actinobacteria decreased in the transverse colon and descending colon. The abundance of Proteobacteria increased in the ascending colon and descending colon, while it decreased in the transverse colon. The abundance of Firmicutes decreased in both the ascending colon and descending colon. In particular, the abundance of Lachnospiraceae members, Bilophila, Oscillospira, Parabacteroides, Desulfovibrio, and Roseburia increased in the ascending colon, while the abundance of Sutterella, Bacteroides, Escherichia, Phascolarctobacterium, Clostridium, Citrobacter, and Klebsiella increased in the descending colon. The Shannon index differed significantly in both the ascending colon and descending colon before and after exposure. Overall, we demonstrate the feasibility of applying the SHIME model to studying the effects of intestinal toxicity on health of chlorinated by-products. The findings of this study improve our understanding of the health impact of CDBPs on the intestinal microbiota and better control of CDBPs in treated water is recommended.
Record ID
Keywords
chlorination disinfection by-products, gut microbiota, health effect, N-nitroso diethylamine, treated water
Subject
Suggested Citation
Wang D, Jiang Y, Wu D, Li S, Wu Z, Zhong Y, Zhang L, Guo C, Li X, Sun L, Li Q, Zhou J, He W. Health Effect of N-Nitroso Diethylamine in Treated Water on Gut Microbiota Using a Simulated Human Intestinal Microbiota System. (2023). LAPSE:2023.2678
Author Affiliations
Wang D: Department of Radiological Protection, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Jiang Y: Department of Clinical Medicine, Clinical Medical School, Guangzhou Medical University, Guangzhou 510440, China
Wu D: Department of Noncommunicable Disease Control and Prevention, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Li S: Department of Student Affairs, Guangzhou Medical University, Guangzhou 510440, China
Wu Z: Department of Environmental Hygiene, School of Public Health, Southern Medical University, Guangzhou 510440, China
Zhong Y: Department of Environmental Health, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Zhang L: Director Office, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Guo C: Department of Environmental Health, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Li X: Department of Environmental Health, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Sun L: Executive Office for Managing Action in Disease Control and Prevention, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Li Q: Department of Environmental Health, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Zhou J: Department of Disinfection and Vector Control, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
He W: Director Office, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Jiang Y: Department of Clinical Medicine, Clinical Medical School, Guangzhou Medical University, Guangzhou 510440, China
Wu D: Department of Noncommunicable Disease Control and Prevention, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Li S: Department of Student Affairs, Guangzhou Medical University, Guangzhou 510440, China
Wu Z: Department of Environmental Hygiene, School of Public Health, Southern Medical University, Guangzhou 510440, China
Zhong Y: Department of Environmental Health, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Zhang L: Director Office, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Guo C: Department of Environmental Health, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Li X: Department of Environmental Health, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Sun L: Executive Office for Managing Action in Disease Control and Prevention, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Li Q: Department of Environmental Health, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Zhou J: Department of Disinfection and Vector Control, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
He W: Director Office, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Journal Name
Processes
Volume
10
Issue
3
First Page
438
Year
2022
Publication Date
2022-02-22
Published Version
ISSN
2227-9717
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Original Submission
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PII: pr10030438, Publication Type: Journal Article
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LAPSE:2023.2678
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doi:10.3390/pr10030438
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[v1] (Original Submission)
Feb 21, 2023
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Feb 21, 2023
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