Refracturing technology is one of the key technologies to recover the productivity of horizontal wells in tight oil reservoirs, and the selection of best candidate wells from target blocks is the basis of this technology. Based on the refracturing production database, this paper analyzes the direct relationship between geological data, initial fracturing completion data, and dynamic production data, and the stimulation effect of refracturing. Considering the interaction among multiple factors, the factors affecting the stimulation effect of refracturing are classified and integrated, and a comprehensive index including geology, engineering, and production is constructed, making this index meaningful both for physical and engineering properties. The XGBoost decision tree model is established to analyze the weight of influence for the comprehensive index of geology, engineering, and production in predicting the stimulation effect of refracturing. A comprehensive decision index of refracturing well selection is formed by combining the above three for performing a fast selection of horizontal candidate wells for fracturing. Taking a horizontal well test area in Songliao Basin as an example, the target wells of refracturing are selected by this method, and field operation is carried out, and a good stimulation effect is achieved. The results show that the comprehensive decision-making index constructed by this method is reliable and has certain guiding significance for well selection and stimulation potential evaluation of tight oil reservoir.