Electric locomotives in AC traction power systems represent a huge single-phase non-linear load and, detrimentally, affect the power quality and the efficiency of the three-phase power grid. Nevertheless, along the last decades, power electronics are being used to mitigate power quality problems in the three-phase power grid. In particular, Rail Power Conditioner (RPC) helps to increase the loading capacity of traction substations and improve the power quality of three-phase power grids. As the main characteristics, an RPC can supply reactive power, suppress current harmonics and overcome currents imbalance of the three-phase power grid. On the other hand, the traction substations may be constituted by different types of power transformers. For instance, single-phase power transformers and open-delta (V/V) power transformers are widely used, while Scott power transformers are less frequently used, since they are more complex and expensive. In this framework, this work presents a review study of RPC topologies, including their operation modes, and a comprehensive comparison between the characteristics of the RPC topologies when using different types of AC traction substations and power transformers. This helps to ensure the correct selection of the RPC topology for a specific application, according to the main structure of the traction substation. Consequently, and based on the established review, it is possible to sort and allocate each RPC topology for limited or wider applications.