This paper investigates the nucleate boiling process of dimethyl ether and selected hydrocarbons. The main goal of this study is to measure the heat transfer coefficients of RE170, R600a, and R601, and to compare them with R134a. The experiments were carried out for heat fluxes up to 70 kW/m2. Experimental results have shown a typical trend that the heat transfer coefficient of flammable refrigerants increases as the heat flux increases. Among the tested fluids, the highest values of heat transfer coefficient were obtained for RE170. Available correlations describing this coefficient showed a deviation of up to 93%, as compared to the data obtained. The new correlation was developed by regression analysis taking into account dimensionless variables affecting the boiling process.