LAPSE:2023.2118v1
Published Article
LAPSE:2023.2118v1
COVID-19-Current Therapeutical Approaches and Future Perspectives
February 21, 2023
Abstract
The ongoing pandemic of coronavirus disease (COVID-19) stimulated an unprecedented international collaborative effort for rapid diagnosis, epidemiologic surveillance, clinical management, prevention, and treatment. This review focuses on the current and new therapeutical approaches, summarizing the viral structure and life cycle, with an emphasis on the specific steps that can be interfered by antivirals: (a) inhibition of viral entry with anti-spike monoclonal antibodies; (b) inhibition of the RNA genome replication with nucleosidic analogs blocking the viral RNA polymerase; (c) inhibition of the main viral protease (Mpro), which directs the formation of the nonstructural proteins. An overview of the immunomodulatory drugs currently used for severe COVID-19 treatment and future therapeutical options are also discussed.
The ongoing pandemic of coronavirus disease (COVID-19) stimulated an unprecedented international collaborative effort for rapid diagnosis, epidemiologic surveillance, clinical management, prevention, and treatment. This review focuses on the current and new therapeutical approaches, summarizing the viral structure and life cycle, with an emphasis on the specific steps that can be interfered by antivirals: (a) inhibition of viral entry with anti-spike monoclonal antibodies; (b) inhibition of the RNA genome replication with nucleosidic analogs blocking the viral RNA polymerase; (c) inhibition of the main viral protease (Mpro), which directs the formation of the nonstructural proteins. An overview of the immunomodulatory drugs currently used for severe COVID-19 treatment and future therapeutical options are also discussed.
Record ID
Keywords
antibodies, antiviral drugs, COVID-19, future therapy, immunomodulators, interferons, nanobodies, treatment
Subject
Suggested Citation
Lupașcu (Moisi) RE, Ilie MI, Velescu BȘ, Udeanu DI, Sultana C, Ruță S, Arsene AL. COVID-19-Current Therapeutical Approaches and Future Perspectives. (2023). LAPSE:2023.2118v1
Author Affiliations
Lupașcu (Moisi) RE: Department of General and Pharmaceutical Microbiology, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, Romania [ORCID]
Ilie MI: Department of General and Pharmaceutical Microbiology, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, Romania
Velescu BȘ: Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, Romania
Udeanu DI: Department of Clinical Laboratory and Food Safety, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, Romania [ORCID]
Sultana C: Department of Virology, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania; Stefan S. Nicolau Institute of Virology, 285 sos Mihai Bravu, 030304 Bucharest, Romania [ORCID]
Ruță S: Department of Virology, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania; Stefan S. Nicolau Institute of Virology, 285 sos Mihai Bravu, 030304 Bucharest, Romania [ORCID]
Arsene AL: Department of General and Pharmaceutical Microbiology, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, Romania [ORCID]
Ilie MI: Department of General and Pharmaceutical Microbiology, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, Romania
Velescu BȘ: Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, Romania
Udeanu DI: Department of Clinical Laboratory and Food Safety, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, Romania [ORCID]
Sultana C: Department of Virology, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania; Stefan S. Nicolau Institute of Virology, 285 sos Mihai Bravu, 030304 Bucharest, Romania [ORCID]
Ruță S: Department of Virology, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania; Stefan S. Nicolau Institute of Virology, 285 sos Mihai Bravu, 030304 Bucharest, Romania [ORCID]
Arsene AL: Department of General and Pharmaceutical Microbiology, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, Romania [ORCID]
Journal Name
Processes
Volume
10
Issue
6
First Page
1053
Year
2022
Publication Date
2022-05-25
ISSN
2227-9717
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Original Submission
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PII: pr10061053, Publication Type: Review
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LAPSE:2023.2118v1
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https://doi.org/10.3390/pr10061053
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Feb 21, 2023
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