Paracetamol-Induced Hypothermia in Rodents: A Review on Pharmacodynamics

Laurențiu Coman; Horia Păunescu; Cristina Isabel Viorica Ghiță; Radu Ciprian Țincu; Sorina Vasile; Delia Cinteza; Ion Fulga; Oana Andreia Coman

LAPSE

Living Archive for Process Systems Engineering

LAPSE:2023.20589

Published Article

LAPSE:2023.20589

Paracetamol-Induced Hypothermia in Rodents: A Review on Pharmacodynamics

Laurențiu Coman, Horia Păunescu, Cristina Isabel Viorica Ghiță, Radu Ciprian Țincu, Sorina Vasile, Delia Cinteza, Ion Fulga, Oana Andreia Coman

March 20, 2023

Paracetamol can induce hypothermia in humans and rodents. The study’s aim is to review the mechanisms of paracetamol-induced hypothermia in rodents or the results issued from in vitro studies on the same species’ tissues (in doses that do not produce hepatic impairment) using the latest developments published in scientific journals over the last 15 years. Available human studies are also analysed. An extensive search in PubMed databases exploring the hypothermic response to paracetamol was conducted. 4669 articles about paracetamol’s effects on body temperature in mice or rats were found. After applying additional filters, 20 articles were selected for review, with 9 of them presented in tabular forms. The analysis of these articles found that the hypothermic effect of paracetamol is due to the inhibition of a cyclooxygenase-1 variant, is potentiated by endothelin receptor antagonists, and can be mediated through GABAA receptors and possibly through transient receptor potential cation channel subfamily A member 1 via N-acetyl-p-benzoquinone imine in the central nervous system. Human studies confirm the in vivo and in vitro experiments in rodents regarding the presence of a hypothermic effect after high, non-toxic doses of paracetamol. Further research is required to understand the mechanisms behind paracetamol’s hypothermic effect in humans.

Record ID

LAPSE:2023.20589

Keywords

hypothermia, mechanism of action, paracetamol, rodents

Subject

Biosystems

Suggested Citation

Coman L, Păunescu H, Ghiță CIV, Țincu RC, Vasile S, Cinteza D, Fulga I, Coman OA. Paracetamol-Induced Hypothermia in Rodents: A Review on Pharmacodynamics. (2023). LAPSE:2023.20589

Author Affiliations

Coman L: Department of Physiology, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
Păunescu H: Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania [ORCID]
Ghiță CIV: Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
Țincu RC: Department of Clinical Toxicology, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania; Critical Care Toxicology Department, Bucharest Clinical Emergency Hospital, 020021 Bucharest, Romania
Vasile S: Infectious Diseases Resident Physician, Guiding Hospital: “Victor Babeș” Hospital of Infectious and Tropical Diseases, 030303 Bucharest, Romania
Cinteza D: Department of Rehabilitation and Physical Medicine, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 030079 Bucharest, Romania; National Institute of Rehabilitation, Physical Medicine and Balneoclimatology, 030079 Bucharest, Romania
Fulga I: Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
Coman OA: Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania

Journal Name

Processes

Volume

10

Issue

4

First Page

687

Year

2022

Publication Date

2022-03-31