The core technology for building a smart space includes the capability to analyse the space for users using various sensors. The purpose of this study was to propose a personalised interactive smart space implementation model driven by the fusion of digital twin (DT) and artificial intelligence (AI) based on electroencephalogram (EEG) data. This study utilised a handheld EEG sensor to identify a user’s emotion information and focused on the connection with the space. A smart space for single-person households that responds to EEG-based biometric information was designed for an interactive space that can improve the current emotional state of the space user. The technical characteristics of DT and AI were analysed to control spatial changes according to the user’s emotional state and to address safety-related issues. Furthermore, a fusion mechanism for DT and AI was developed for intelligent motor control to change the dimensions of the space in order to improve the EEG state of the user. In addition, using an AI model that converts EEG data into emotional state information, the user’s emotional state was analysed, and key issues related to the spatial dimensions and change of space that induce psychological stability were investigated.