Pollutant emissions have been a topic of interest in the last decades. Not only environmentalists but also governments are taking rapid action to reduce emissions. As one of the main contributors, the transport sector is being subjected to strict scrutiny to ensure it complies with the short and long-term regulations. The measures imposed by governments clearly involve all the stakeholders in the logistics sector, from road authorities and logistic operators to truck manufacturers. The improvement of traffic conditions is one of the perspectives in which the reduction of emissions is being addressed. Optimization of traffic flow, avoidance of unnecessary stops, control of the cruise speed, and coordination of trips in an energy-efficient way are necessary steps to remain compliant with the upcoming regulations. In this study, we have estimated the CO2 and NOx emissions in heavy-duty vehicles while traversing signalized intersections, and we examined the differences between various behavioral scenarios. We found a consistent trend indicating that avoiding a stop can potentially reduce CO2 and NOx emissions by up to 0.32kg and 1.8g, respectively. Furthermore, an upper bound for the yearly CO2 savings is provided for the case of The Netherlands. A reduction of 3.2% of the total CO2 emitted by heavy-duty vehicles is estimated. These results put traffic control in the main scene as a yet unexplored dimension to control pollutant emissions, enabling authorities to more accurately estimate cost−benefit plans for traffic control system investments.