Work processes and sociological structures can differ significantly between organizations. These organizational aspects determine user behavior, which in turn exerts considerable influence on the key performance indicators of artificial lighting systems. Accordingly, the use of generalized assumptions about user behavior in the building design phase can lead to large discrepancies between design and operation. In the following work, the possible influences of different occupancy schemes, an essential aspect of user behavior and shaped by the organization, on energy demand and workplace-related daylight dose are evaluated. For this purpose, calculations are made based on real measurement data of an open-plan office with zoned lighting. Multi-level calculation models are used to determine improved user distributions in the room to ensure optimization according to the desired target criteria. The results show that occupancy schemes have a significant impact on energy demand, contributing significantly to overall building performance, but only slightly to workplace-related light exposure rates in terms of total daily light dose. A correlated influence on the target criteria could not be demonstrated, but given the minor influence on daily light dose, the optimization of planning and operation can be focused on energy efficiency.