LAPSE:2023.11283
Published Article
LAPSE:2023.11283
Review of CFD-DEM Modeling of Wet Fluidized Bed Granulation and Coating Processes
February 27, 2023
Abstract
Wet fluidized bed granulation and coating processes have been widely used in the pharmaceutical and food industries. The complex gas−solid flow coupled with heat and mass transfer in such processes made it hard to form complete control over the apparatuses. To serve better design, scaling-up, and optimization of granulators and coaters, the underlying micro-scale mechanisms must be clarified. Computational fluid dynamics coupled with the discrete element method (CFD-DEM) provides a useful tool to study in-depth the gas-solid hydrodynamics of the granulation and coating processes. This review firstly introduced the fundamental theory of CFD-DEM from governing equations, force calculation, and coupling schemes. Then the application of CFD-DEM in simulating wet fluidized bed granulation and coating was presented. Specifically, the research focus and the role of CFD-DEM in resolving issues were discussed. Finally, the outlook on the development of CFD-DEM in the context of granulation and coating was given.
Wet fluidized bed granulation and coating processes have been widely used in the pharmaceutical and food industries. The complex gas−solid flow coupled with heat and mass transfer in such processes made it hard to form complete control over the apparatuses. To serve better design, scaling-up, and optimization of granulators and coaters, the underlying micro-scale mechanisms must be clarified. Computational fluid dynamics coupled with the discrete element method (CFD-DEM) provides a useful tool to study in-depth the gas-solid hydrodynamics of the granulation and coating processes. This review firstly introduced the fundamental theory of CFD-DEM from governing equations, force calculation, and coupling schemes. Then the application of CFD-DEM in simulating wet fluidized bed granulation and coating was presented. Specifically, the research focus and the role of CFD-DEM in resolving issues were discussed. Finally, the outlook on the development of CFD-DEM in the context of granulation and coating was given.
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Keywords
CFD-DEM, coating, fluidized bed, granulation
Subject
Suggested Citation
Song Y, Zhou T, Bai R, Zhang M, Yang H. Review of CFD-DEM Modeling of Wet Fluidized Bed Granulation and Coating Processes. (2023). LAPSE:2023.11283
Author Affiliations
Song Y: Department of Energy and Power Engineering, Tsinghua University, Beijing 100084, China; Key Laboratory for Thermal Science and Power Engineering of Ministry of Education, Tsinghua University, Beijing 100084, China
Zhou T: Department of Energy and Power Engineering, Tsinghua University, Beijing 100084, China; Key Laboratory for Thermal Science and Power Engineering of Ministry of Education, Tsinghua University, Beijing 100084, China
Bai R: Department of Energy and Power Engineering, Tsinghua University, Beijing 100084, China; Key Laboratory for Thermal Science and Power Engineering of Ministry of Education, Tsinghua University, Beijing 100084, China
Zhang M: Department of Energy and Power Engineering, Tsinghua University, Beijing 100084, China; Key Laboratory for Thermal Science and Power Engineering of Ministry of Education, Tsinghua University, Beijing 100084, China
Yang H: Department of Energy and Power Engineering, Tsinghua University, Beijing 100084, China; State Key Laboratory of Power System and Generation Equipment, Tsinghua University, Beijing 100084, China
Zhou T: Department of Energy and Power Engineering, Tsinghua University, Beijing 100084, China; Key Laboratory for Thermal Science and Power Engineering of Ministry of Education, Tsinghua University, Beijing 100084, China
Bai R: Department of Energy and Power Engineering, Tsinghua University, Beijing 100084, China; Key Laboratory for Thermal Science and Power Engineering of Ministry of Education, Tsinghua University, Beijing 100084, China
Zhang M: Department of Energy and Power Engineering, Tsinghua University, Beijing 100084, China; Key Laboratory for Thermal Science and Power Engineering of Ministry of Education, Tsinghua University, Beijing 100084, China
Yang H: Department of Energy and Power Engineering, Tsinghua University, Beijing 100084, China; State Key Laboratory of Power System and Generation Equipment, Tsinghua University, Beijing 100084, China
Journal Name
Processes
Volume
11
Issue
2
First Page
382
Year
2023
Publication Date
2023-01-26
ISSN
2227-9717
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Original Submission
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PII: pr11020382, Publication Type: Review
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LAPSE:2023.11283
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https://doi.org/10.3390/pr11020382
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Feb 27, 2023
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