Automated fault detection and diagnostics in building systems using machine learning (ML) can be applied to commercial buildings and can result in increased efficiency and savings. Using ML for FDD brings the benefit of advancing the analytics of a building. An automated process was developed to provide ML-based building analytics to building engineers and operators with minimal training. The process can be applied to buildings with a variety of configurations, which saves time and manual effort in a fault analysis. Classification analysis is used for fault detection and diagnostics. An ML analysis is defined which introduces advanced diagnostics with metrics to quantify a fault’s impact in the system and rank detected faults in order of impact severity. Explanations of the methodology used for the ML analysis include a description of the algorithms used. The analysis was applied to a building on the Texas A&M University campus where the results are shown to illustrate the performance of the process using measured data from a building.