LAPSE:2021.0705
Published Article
LAPSE:2021.0705
Ad-Dressing Stem Cells: Hydrogels for Encapsulation
August 2, 2021
Regenerative medicine is a novel scientific field that employs the use of stem cells as cell-based therapy for the regeneration and functional restoration of damaged tissues and organs. Stem cells bear characteristics such as the capacity for self-renewal and differentiation towards specific lineages and, therefore, serve as a backup reservoir in case of tissue injuries. Therapeutically, they can be autologously or allogeneically transplanted for tissue regeneration; however, allogeneic stem cell transplantation can provoke host immune responses leading to a host-versus-transplant reaction. A probable solution to this problem is stem cell encapsulation, a technique that utilizes various biomaterials for the creation of a semi-permeable membrane that encases the stem cells. Stem cell encapsulation can be accomplished by employing a great variety of natural and/or synthetic hydrogels and offers many benefits in regenerative medicine, including protection from the host’s immune system and mechanical stress, improved cell viability, proliferation and differentiation, cryopreservation and controlled and continuous delivery of the stem-cell-secreted therapeutic agents. Here, in this review, we report and discuss almost all natural and synthetic hydrogels used in stem cell encapsulation, along with the benefits that these materials, alone or in combination, could offer to cell therapy through functional cell encapsulation.
Record ID
Keywords
biomaterials, encapsulation, hydrogels, stem cells
Subject
Suggested Citation
Kandilogiannakis L, Filidou E, Kolios G, Paspaliaris V. Ad-Dressing Stem Cells: Hydrogels for Encapsulation. (2021). LAPSE:2021.0705
Author Affiliations
Kandilogiannakis L: Laboratory of Pharmacology, Faculty of Medicine, Democritus University of Thrace, Dragana, 68100 Alexandroupolis, Greece
Filidou E: Laboratory of Pharmacology, Faculty of Medicine, Democritus University of Thrace, Dragana, 68100 Alexandroupolis, Greece [ORCID]
Kolios G: Laboratory of Pharmacology, Faculty of Medicine, Democritus University of Thrace, Dragana, 68100 Alexandroupolis, Greece [ORCID]
Paspaliaris V: Tithon Biotech Inc., San Diego, CA 92127, USA
Filidou E: Laboratory of Pharmacology, Faculty of Medicine, Democritus University of Thrace, Dragana, 68100 Alexandroupolis, Greece [ORCID]
Kolios G: Laboratory of Pharmacology, Faculty of Medicine, Democritus University of Thrace, Dragana, 68100 Alexandroupolis, Greece [ORCID]
Paspaliaris V: Tithon Biotech Inc., San Diego, CA 92127, USA
Journal Name
Processes
Volume
9
Issue
1
First Page
pr9010011
Year
2020
Publication Date
2020-12-23
ISSN
2227-9717
Version Comments
Original Submission
Other Meta
PII: pr9010011, Publication Type: Review
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Published Article
LAPSE:2021.0705
This Record
External Link
https://doi.org/10.3390/pr9010011
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402
Version History
[v1] (Original Submission)
Aug 2, 2021
Verified by curator on
Aug 2, 2021
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v1
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URL Here
https://psecommunity.org/LAPSE:2021.0705
Record Owner
Calvin Tsay
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