Anaerobic digestion is an efficient technology for a sustainable conversion of various organic wastes such as animal manure, municipal solid waste, agricultural residues and industrial waste into biogas. This technology offers a unique set of benefits, some of which include a good waste management technique, enhancement in the ecology of rural areas, improvement in health through a decrease of pathogens and optimization of the energy consumption of communities. The biogas produced through anaerobic digestion varies in composition, but it consists mainly of carbon dioxide methane together with a low quantity of trace gases. The variation in biogas composition are dependent on some factors namely the substrate type being digested, pH, operating temperature, organic loading rate, hydraulic retention time and digester design. However, the type of substrate used is of greater interest due to the direct dependency of microorganism activities on the nutritional composition of the substrate. Therefore, the aim of this review study is to provide a detailed analysis of the various types of organic wastes that have been used as a substrate for the sustainable production of biogas. Biogas formation from various substrates reported in the literature were investigated, an analysis and characterization of these substrates provided the pro and cons associated with each substrate. The findings obtained showed that the methane yield for all animal manure varied from 157 to 500 mL/gVS with goat and pig manure superseding the other animal manure whereas lignocellulose biomass varied from 160 to 212 mL/gVS. In addition, organic municipal solid waste and industrial waste showed methane yield in the ranges of 143−516 mL/gVS and 25−429 mL/gVS respectively. These variations in methane yield are primarily attributed to the nutritional composition of the various substrates.