LAPSE:2020.1143
Published Article
LAPSE:2020.1143
Andrographis paniculata Extract Relieves Pain and Inflammation in Monosodium Iodoacetate-Induced Osteoarthritis and Acetic Acid-Induced Writhing in Animal Models
November 9, 2020
Osteoarthritis (OA), being the most prominent degenerative joint disease is affecting millions of elderly people worldwide. Although Andrographis paniculata is an ethnic medicine with a long history of being used as analgesic agent, no study using a monosodium iodoacetate (MIA) model has investigated its potential activities against OA. In this study, experimental OA was induced in rats with a knee injection of MIA, which represents the pathological characteristics of OA in humans. A. paniculata extract (APE) substantially reversed the loss of hind limb weight-bearing and the cartilage damage resulted from the OA induction in rats. Additionally, the levels of serum pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α as well as the concentration of matrix metalloproteinases, including MMP-1, MMP-3, MMP-8, and MMP-13 were decreased by APE administration. Acetic acid-induced writhing responses in mice which quantitatively measure pain were significantly reduced by APE. In vitro, APE inhibited the generation of NO and downregulated the expression of IL-1β, IL-6, COX-2, and iNOS in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. The above results suggest the potential use APE as a therapeutic agent against OA.
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Keywords
analgesic, Andrographis paniculata, anti-inflammatory, osteoarthritis, pain
Subject
Suggested Citation
Lee D, Baek CY, Hwang JH, Kim MY. Andrographis paniculata Extract Relieves Pain and Inflammation in Monosodium Iodoacetate-Induced Osteoarthritis and Acetic Acid-Induced Writhing in Animal Models. (2020). LAPSE:2020.1143
Author Affiliations
Lee D: Department of Herbal Pharmacology, College of Korean Medicine, Gachon University, 1342 Seongnamdae-ro, Sujeong-gu, Seongnam 13120, Korea [ORCID]
Baek CY: Department of Herbal Pharmacology, College of Korean Medicine, Gachon University, 1342 Seongnamdae-ro, Sujeong-gu, Seongnam 13120, Korea
Hwang JH: Natural F&P Corp., 767, Sinsu-ro, Suji-gu, Yongin-si, Gyeonggi-do 16827, Korea
Kim MY: Natural F&P Corp., 767, Sinsu-ro, Suji-gu, Yongin-si, Gyeonggi-do 16827, Korea
Baek CY: Department of Herbal Pharmacology, College of Korean Medicine, Gachon University, 1342 Seongnamdae-ro, Sujeong-gu, Seongnam 13120, Korea
Hwang JH: Natural F&P Corp., 767, Sinsu-ro, Suji-gu, Yongin-si, Gyeonggi-do 16827, Korea
Kim MY: Natural F&P Corp., 767, Sinsu-ro, Suji-gu, Yongin-si, Gyeonggi-do 16827, Korea
Journal Name
Processes
Volume
8
Issue
7
Article Number
E873
Year
2020
Publication Date
2020-07-20
Published Version
ISSN
2227-9717
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Original Submission
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PII: pr8070873, Publication Type: Journal Article
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Published Article
LAPSE:2020.1143
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doi:10.3390/pr8070873
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[v1] (Original Submission)
Nov 9, 2020
Verified by curator on
Nov 9, 2020
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v1
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https://psecommunity.org/LAPSE:2020.1143
Original Submitter
Calvin Tsay
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