LAPSE:2020.1139
Published Article
LAPSE:2020.1139
Development of a Freeze-Drying Stage for In-Situ µ-CT Measurements
November 9, 2020
This paper shows the development of a freeze-drying stage for in-situ μ-CT measurements. The stage can operate in a temperature range of −40 °C up to 70 °C, and a pressure range from atmospheric pressure to 7 Pa at the sample holder. To get the best visualization of the probe, it is fundamental that the materials around the sample holder are not absorbing most of the radiation. For this reason, we built an axial symmetrical stage built out of polyetheretherketon (PEEK). A test of the stage by different freeze-drying experiments with maltodextrin and sucrose particles and solutions demonstrated its suitability to visualize the freeze-drying processes in-situ. It was possible to track the drying front during the process by radiographic and tomographic measurements, as well as to visually resolve the ice crystals and porous structure in tomographic measurements. Using different samples and process parameters, we showed that the freeze-drying stage is not only suitable for in-situ µ-CT measurements, but also allows us to use the stage for other imaging methods such as neutron imaging, and for any sample where a controlled environment is needed.
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Keywords
freeze-drying, in-situ, lyophilization, pore network, sublimation front, X-ray, µ-CT
Suggested Citation
Hilmer M, Gruber S, Foerst P. Development of a Freeze-Drying Stage for In-Situ µ-CT Measurements. (2020). LAPSE:2020.1139
Author Affiliations
Hilmer M: Chair of Process Systems Engineering, TUM School of Life Sciences, Technical University of Munich, Gregor-Mendel-Str. 4, 85354 Freising, Germany [ORCID]
Gruber S: Chair of Process Systems Engineering, TUM School of Life Sciences, Technical University of Munich, Gregor-Mendel-Str. 4, 85354 Freising, Germany
Foerst P: Chair of Process Systems Engineering, TUM School of Life Sciences, Technical University of Munich, Gregor-Mendel-Str. 4, 85354 Freising, Germany
Gruber S: Chair of Process Systems Engineering, TUM School of Life Sciences, Technical University of Munich, Gregor-Mendel-Str. 4, 85354 Freising, Germany
Foerst P: Chair of Process Systems Engineering, TUM School of Life Sciences, Technical University of Munich, Gregor-Mendel-Str. 4, 85354 Freising, Germany
Journal Name
Processes
Volume
8
Issue
7
Article Number
E869
Year
2020
Publication Date
2020-07-18
Published Version
ISSN
2227-9717
Version Comments
Original Submission
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PII: pr8070869, Publication Type: Journal Article
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Published Article
LAPSE:2020.1139
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External Link
doi:10.3390/pr8070869
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Version History
[v1] (Original Submission)
Nov 9, 2020
Verified by curator on
Nov 9, 2020
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v1
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URL Here
https://psecommunity.org/LAPSE:2020.1139
Original Submitter
Calvin Tsay
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