LAPSE:2020.1037
Published Article
LAPSE:2020.1037
Hair Growth Effect of Emulsion Extracted Brevilin A, a JAK3 Inhibitor, from Centipeda minima
October 26, 2020
Janus kinase 3 (JAK3) inhibitors have been used effectively in the treatment of several cases of alopecia universalis and its variants. Our study aims to evaluate whether the emulsion extract of brevilin A from Centipeda minima (CMX) stimulates hair regrowth in a clinical trial, as a JAK3 inhibitor, combined with network pharmacology-based analysis. CMX showed potent inhibition of JAK3 in a concentration-dependent manner. Significant differences in total hair count, terminal hair count, and anagen hair count from the baseline to 24 weeks were observed between the placebo and CMX subjects. The gene set enrichment analysis showed that the targets of CMX are mainly associated with the JAK-STAT signaling pathway, cytokine−cytokine receptor interactions, and the MAPK signaling pathway. This study suggests that the medicinal herbal extract CMX is useful in the treatment of mild to moderate vertex balding that contribute to the visible improvements in hair growth observed in treated patients.
Record ID
Keywords
brevilin A, Centipeda minima, hair growth, Janus kinase-signal transducer and activator of transcription signaling pathway, network pharmacology
Subject
Suggested Citation
Kim BH, Lee WY, Trinh TA, Pyo JS, Lee S, Kim CE, Lee DH, Park ES, Kang KS. Hair Growth Effect of Emulsion Extracted Brevilin A, a JAK3 Inhibitor, from Centipeda minima. (2020). LAPSE:2020.1037
Author Affiliations
Kim BH: D. Nature Co., Ltd., Seongnam 13174, Korea
Lee WY: College of Korean Medicine, Gachon University, Seongnam 13120, Korea [ORCID]
Trinh TA: College of Korean Medicine, Gachon University, Seongnam 13120, Korea [ORCID]
Pyo JS: College of Pharmacy, Kyungsung University, Busan 48434, Korea
Lee S: College of Pharmacy, Keimyung University, 1095 Dalgubeoldaero, Dalseo-gu, Daegu 42601, Korea
Kim CE: College of Korean Medicine, Gachon University, Seongnam 13120, Korea [ORCID]
Lee DH: Korea Dermatology Research Institute, GFC Life Science Co., Ltd, Seongnam 13517, Korea
Park ES: School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea
Kang KS: College of Korean Medicine, Gachon University, Seongnam 13120, Korea
Lee WY: College of Korean Medicine, Gachon University, Seongnam 13120, Korea [ORCID]
Trinh TA: College of Korean Medicine, Gachon University, Seongnam 13120, Korea [ORCID]
Pyo JS: College of Pharmacy, Kyungsung University, Busan 48434, Korea
Lee S: College of Pharmacy, Keimyung University, 1095 Dalgubeoldaero, Dalseo-gu, Daegu 42601, Korea
Kim CE: College of Korean Medicine, Gachon University, Seongnam 13120, Korea [ORCID]
Lee DH: Korea Dermatology Research Institute, GFC Life Science Co., Ltd, Seongnam 13517, Korea
Park ES: School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea
Kang KS: College of Korean Medicine, Gachon University, Seongnam 13120, Korea
Journal Name
Processes
Volume
8
Issue
7
Article Number
E767
Year
2020
Publication Date
2020-06-30
Published Version
ISSN
2227-9717
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Original Submission
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PII: pr8070767, Publication Type: Journal Article
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Published Article
LAPSE:2020.1037
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External Link
doi:10.3390/pr8070767
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Version History
[v1] (Original Submission)
Oct 26, 2020
Verified by curator on
Oct 26, 2020
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v1
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https://psecommunity.org/LAPSE:2020.1037
Original Submitter
Calvin Tsay
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