LAPSE:2020.0990
Published Article
LAPSE:2020.0990
Valorization of Globe Artichoke (Cynara scolymus) Agro-Industrial Discards, Obtaining an Extract with a Selective Effect on Viability of Cancer Cell Lines
Diana Noriega-Rodríguez, Carmen Soto-Maldonado, Cristian Torres-Alarcón, Lorenzo Pastrana-Castro, Caroline Weinstein-Oppenheimer, María Elvira Zúñiga-Hansen
September 23, 2020
Globe artichoke (Cynara scolymus L.) is considered one of the most significant sources of phenolic antioxidants in nature. However, more than 60% of its total volume is discarded for consumption purposes, making available an abundant, inexpensive and profitable source of natural antioxidants in the discarded fractions. Polyphenolic antioxidants from a South American variety of artichoke agro-industrial discards (external bracts and stems) were obtained by mild extraction processes. Best results were achieved at 40 °C, 75% of ethanol and 10 min of reaction, obtaining 2.16 g gallic acid equivalent (GAE)/100 g of total phenolic compounds (TPC) and 55,472.34 µmol Trolox equivalent (TE)/100 g of antioxidant capacity (oxygen radical absorbance capacity (ORAC)). High-performance liquid chromatography (HPLC) analyses determined that caffeoylquinic acids comprise up to 85% of the total polyphenolic content, and only around 5% are flavonoids. Inulin content in the artichokes residues was recovered (48.4% dry weight (dw)), resulting in an extract with 28% of inulin in addition to the aforementioned antioxidant capacity. The artichoke discard extract in a concentration of 500 mg/L produced a strong decrease in Caco-2 and MCF-7 cancer cell lines viability, whereas healthy fibroblasts maintained their viability when the extract was concentrated at 1500 mg/L. These results suggest that the artichoke extract presents a good anti-proliferative potential effect on Caco-2 and MCF-7 cells.
Keywords
antioxidant activity, artichoke discards, Caco-2, inulin, MCF-7, polyphenols
Suggested Citation
Noriega-Rodríguez D, Soto-Maldonado C, Torres-Alarcón C, Pastrana-Castro L, Weinstein-Oppenheimer C, Zúñiga-Hansen ME. Valorization of Globe Artichoke (Cynara scolymus) Agro-Industrial Discards, Obtaining an Extract with a Selective Effect on Viability of Cancer Cell Lines. (2020). LAPSE:2020.0990
Author Affiliations
Noriega-Rodríguez D: Departamento de Química Analítica y Alimentaria, Universidade de Vigo, Circunvalación ao Campus Universitario, 36310 Vigo, Pontevedra, Spain
Soto-Maldonado C: Centro Regional de Estudios en Alimentos Saludables, Av. Universidad 330, Curauma-Placilla, Valparaíso 2373223, Chile [ORCID]
Torres-Alarcón C: Escuela de Ingeniería Bioquímica, Pontificia Universidad Católica de Valparaíso, Av. Brasil 2085, Valparaíso 2362803, Chile
Pastrana-Castro L: International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330 Braga, Portugal
Weinstein-Oppenheimer C: Escuela de Química y Farmacia, Facultad de Farmacia, Universidad de Valparaíso, Av. Gran Bretaña 1093, Valparaíso 2360102, Chile
Zúñiga-Hansen ME: Centro Regional de Estudios en Alimentos Saludables, Av. Universidad 330, Curauma-Placilla, Valparaíso 2373223, Chile; Escuela de Ingeniería Bioquímica, Pontificia Universidad Católica de Valparaíso, Av. Brasil 2085, Valparaíso 2362803, Chile
Journal Name
Processes
Volume
8
Issue
6
Article Number
E715
Year
2020
Publication Date
2020-06-20
Published Version
ISSN
2227-9717
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Original Submission
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PII: pr8060715, Publication Type: Journal Article
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LAPSE:2020.0990
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doi:10.3390/pr8060715
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Sep 23, 2020
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Sep 23, 2020
 
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Original Submitter
Calvin Tsay
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