LAPSE:2020.0774
Published Article
LAPSE:2020.0774
Phytochemical Profile, Antioxidant and Antitumor Activities of Green Grape Juice
July 2, 2020
(1) Plants, due to their phytochemicals, have long been known for their pharmacological potential and medicinal value. Verjuice, the acidic juice of unripe green grape, is still poorly characterized in terms of its chemical composition and biological activities. (2) In this study, we characterized the chemical composition, antioxidant and antitumor potential of verjuice extract. Folin−Ciocalteu and aluminum chloride reagents were used to identify the total phenol and total flavonoid composition. Various conventional methods were used to quantify the alkaloids and tannins. DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging assay and Neutral Red assay were used to assess the antioxidant and antitumor activities, respectively. (3) We showed that the verjuice extract contains alkaloids, tannins, and a high quantity of total flavonoids and total phenols. Besides its antioxidant activity, verjuice significantly repressed human pulmonary adenocarcinoma (A549) cells’ viability in both dose- and time-dependent manners. Moreover, verjuice extract significantly enhanced the anticancer potential of cisplatin. (4) Altogether, these observations suggest a potential use of verjuice as a natural antitumor remedy.
Record ID
Keywords
anti-proliferative, antioxidant, phytochemicals, pulmonary adenocarcinoma, unripe grape juice, verjuice
Suggested Citation
Nasser M, Cheikh-Ali H, Hijazi A, Merah O, Al-Rekaby AEAN, Awada R. Phytochemical Profile, Antioxidant and Antitumor Activities of Green Grape Juice. (2020). LAPSE:2020.0774
Author Affiliations
Nasser M: Doctoral School of Science and Technology, Research Plateform for Environmental Sience (PRASE), Lebanese University, P.O. Box 5, Beirut, Lebanon; Anticancer Therapeutic Approaches Group (ATAC), Rammal Hassan Rammal Research Laboratory, Biology Department,
Cheikh-Ali H: Doctoral School of Science and Technology, Research Plateform for Environmental Sience (PRASE), Lebanese University, P.O. Box 5, Beirut, Lebanon
Hijazi A: Doctoral School of Science and Technology, Research Plateform for Environmental Sience (PRASE), Lebanese University, P.O. Box 5, Beirut, Lebanon; Anticancer Therapeutic Approaches Group (ATAC), Rammal Hassan Rammal Research Laboratory, Biology Department,
Merah O: Laboratoire de Chimie Agro-industrielle (LCA), Université de Toulouse, INRA, INPT, 31030 Toulouse, France; Département Génie Biologique, IUT A, Université Paul Sabatier, 24 rue d’Embaquès, 32000 Auch, France [ORCID]
Al-Rekaby AEAN: Department of Biology, College of Science, Al Mustansiriyah University, P.O. Box 14022, Baghdad, Iraq
Awada R: Doctoral School of Science and Technology, Research Plateform for Environmental Sience (PRASE), Lebanese University, P.O. Box 5, Beirut, Lebanon; Anticancer Therapeutic Approaches Group (ATAC), Rammal Hassan Rammal Research Laboratory, Biology Department,
Cheikh-Ali H: Doctoral School of Science and Technology, Research Plateform for Environmental Sience (PRASE), Lebanese University, P.O. Box 5, Beirut, Lebanon
Hijazi A: Doctoral School of Science and Technology, Research Plateform for Environmental Sience (PRASE), Lebanese University, P.O. Box 5, Beirut, Lebanon; Anticancer Therapeutic Approaches Group (ATAC), Rammal Hassan Rammal Research Laboratory, Biology Department,
Merah O: Laboratoire de Chimie Agro-industrielle (LCA), Université de Toulouse, INRA, INPT, 31030 Toulouse, France; Département Génie Biologique, IUT A, Université Paul Sabatier, 24 rue d’Embaquès, 32000 Auch, France [ORCID]
Al-Rekaby AEAN: Department of Biology, College of Science, Al Mustansiriyah University, P.O. Box 14022, Baghdad, Iraq
Awada R: Doctoral School of Science and Technology, Research Plateform for Environmental Sience (PRASE), Lebanese University, P.O. Box 5, Beirut, Lebanon; Anticancer Therapeutic Approaches Group (ATAC), Rammal Hassan Rammal Research Laboratory, Biology Department,
Journal Name
Processes
Volume
8
Issue
5
Article Number
E507
Year
2020
Publication Date
2020-04-26
Published Version
ISSN
2227-9717
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Original Submission
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PII: pr8050507, Publication Type: Journal Article
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LAPSE:2020.0774
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doi:10.3390/pr8050507
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[v1] (Original Submission)
Jul 2, 2020
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Jul 2, 2020
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https://psecommunity.org/LAPSE:2020.0774
Original Submitter
Calvin Tsay
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