Two pilot-scale tests were carried out to assess if biodrying could be an effective process for the treatment of light fraction produced by an hydromechanical pre-treatment in an anaerobic digestion plant. The trials were performed using two pilot-scale stainless steel cylindrical reactors of 750 L capacity. Two tests were performed: in Test 1, only the light fraction was used; in Test 2, the light fraction was mixed with a bulking agent composed of garden and pruning waste. In Test 2, the highest temperature (71 °C) in a short time (8 days) was reached. An average water content reduction of 78% in Test 1 and 61% in Test 2 was measured, leading to similar reductions of weight (47−48%) and volume (27−29%). A high biological stability was measured on the final light fraction samples collected from both the tests. Furthermore, the lower heating value obtained after the biodrying treatment complies with the quality specification of the European standard on refuse-derived fuels.