This study systematically investigates the pressure fluctuation in the riser of a dual interconnected circulating fluidized bed (CFB) representing a 10 kWth cold-flow model (CFM) of a chemical-looping combustion (CLC) system. Specifically, a single-species system (SSS) and a binary-mixtures system (BMS) of particles with different sizes and densities were utilized. The pressure fluctuation was analyzed using the fast Fourier transform (FFT) method. The effect of introducing a second particle, changing the inventory, composition (i.e., 5, 10 to 20 wt.%), particle size ratio, and fluidization velocity were investigated. For typical SSS experiments, the results were similar to those scarcely reported in the literature, where the pressure fluctuation intensity was influenced by varying the initial operating conditions. The pressure fluctuations of BMS were investigated in detail and compared with those obtained from SSS experiments. BMS exhibited different behaviour; it had intense pressure fluctuation in the air reactor and in the riser when compared to SSS experiments. The standard deviation (SD) of the pressure fluctuation was found to be influenced by the fluidization regime and initial operating conditions, while the power spectrum density (PSD) values were more sensitive to the presence of the particles with the higher terminal velocity in the binary mixture.