LAPSE:2019.1150
Published Article
LAPSE:2019.1150
Global Sensitivity Analysis of a Spray Drying Process
November 24, 2019
Spray drying is a key unit operation used to achieve particulate products of required properties. Despite its widespread use, the product and process design, as well as the process control remain highly empirical and depend on trial and error experiments. Studying the effect of operational parameters experimentally is tedious, time consuming, and expensive. In this paper, we carry out a model-based global sensitivity analysis (GSA) of the process. Such an exercise allows us to quantify the impact of different process parameters, many of which interact with each other, on the product properties and conditions that have an impact on the functionality of the final drug product. Moreover, classical sensitivity analysis using the Sobol-based sensitivity indices was supplemented by a polynomial chaos-based sensitivity analysis, which proved to be an efficient method to reduce the computational cost of the GSA. The results obtained demonstrate the different response dependencies of the studied variables, which helps to identify possible control strategies that can result in major robustness for the spray drying process.
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Keywords
global sensitivity analysis, pharmaceutical manufacturing, polynomial chaos, quality by design, spray drying
Subject
Suggested Citation
Bhonsale S, Muñoz López CA, Van Impe J. Global Sensitivity Analysis of a Spray Drying Process. (2019). LAPSE:2019.1150
Author Affiliations
Bhonsale S: Chemical and BioProcess Technology and Control, Department of Chemical Engineering, KU Leuven, Gebroeders de Smetstraat 1, 9000 Ghent, Belgium [ORCID]
Muñoz López CA: Chemical and BioProcess Technology and Control, Department of Chemical Engineering, KU Leuven, Gebroeders de Smetstraat 1, 9000 Ghent, Belgium [ORCID]
Van Impe J: Chemical and BioProcess Technology and Control, Department of Chemical Engineering, KU Leuven, Gebroeders de Smetstraat 1, 9000 Ghent, Belgium [ORCID]
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Muñoz López CA: Chemical and BioProcess Technology and Control, Department of Chemical Engineering, KU Leuven, Gebroeders de Smetstraat 1, 9000 Ghent, Belgium [ORCID]
Van Impe J: Chemical and BioProcess Technology and Control, Department of Chemical Engineering, KU Leuven, Gebroeders de Smetstraat 1, 9000 Ghent, Belgium [ORCID]
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Journal Name
Processes
Volume
7
Issue
9
Article Number
E562
Year
2019
Publication Date
2019-08-23
Published Version
ISSN
2227-9717
Version Comments
Original Submission
Other Meta
PII: pr7090562, Publication Type: Journal Article
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Published Article
LAPSE:2019.1150
This Record
External Link
doi:10.3390/pr7090562
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Version History
[v1] (Original Submission)
Nov 24, 2019
Verified by curator on
Nov 24, 2019
This Version Number
v1
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URL Here
https://psecommunity.org/LAPSE:2019.1150
Original Submitter
Calvin Tsay
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