LAPSE:2018.0305
Published Article
LAPSE:2018.0305
Process Modification of Pharmaceutical Tablet Manufacturing Operations: An Eco-Efficiency Approach
July 31, 2018
Abstract
A process improvement in a tablet manufacturing process within a pharmaceutical industry was carried out based on an eco-efficiency approach. As it is one of the most energy consuming processes in the production line, the tablet manufacturing process was considered. It has the highest production volume with a complicated and long manufacturing product life cycle. Data were collected on energy inputs and emissions data for the stages of powder direct mixing, particle size reduction, and tableting. A straightforward approach was then used to analyze environmental impacts in terms of GHG emissions. Non- added value steps were removed from the product life cycle process, which has led to significant time and cost savings, as well as to a reduction in the emission. Annual economic savings have been achieved, a time reduction of approximately 71% was attained, and the reduction in GHG emissions and energy cost were 73.2%. The g CO₂eq per tablet reduction has been calculated within the process improvement to be 2.06 g CO₂eq per tablet instead of 7.71 g CO₂eq per tablet.
A process improvement in a tablet manufacturing process within a pharmaceutical industry was carried out based on an eco-efficiency approach. As it is one of the most energy consuming processes in the production line, the tablet manufacturing process was considered. It has the highest production volume with a complicated and long manufacturing product life cycle. Data were collected on energy inputs and emissions data for the stages of powder direct mixing, particle size reduction, and tableting. A straightforward approach was then used to analyze environmental impacts in terms of GHG emissions. Non- added value steps were removed from the product life cycle process, which has led to significant time and cost savings, as well as to a reduction in the emission. Annual economic savings have been achieved, a time reduction of approximately 71% was attained, and the reduction in GHG emissions and energy cost were 73.2%. The g CO₂eq per tablet reduction has been calculated within the process improvement to be 2.06 g CO₂eq per tablet instead of 7.71 g CO₂eq per tablet.
Record ID
Keywords
carbon emission, eco-efficiency, pharmaceutical industry, process improvement, tableting
Subject
Suggested Citation
Hindiyeh M, Altalafha T, Al-Naerat M, Saidan H, Al-Salaymeh A, Sbeinati L, Saidan MN. Process Modification of Pharmaceutical Tablet Manufacturing Operations: An Eco-Efficiency Approach. (2018). LAPSE:2018.0305
Author Affiliations
Hindiyeh M: Civil and Environmental Engineering Department, School of Natural Resources Engineering, German Jordanian University, Madaba 11180, Jordan
Altalafha T: Program of Environmental Engineering and Climate Change (MAPEC), School of Engineering, The University of Jordan, Amman 11942, Jordan
Al-Naerat M: Program of Environmental Engineering and Climate Change (MAPEC), School of Engineering, The University of Jordan, Amman 11942, Jordan
Saidan H: The World Islamic Sciences and Education University, Finance and Management Faculty, Amman 11947, Jordan
Al-Salaymeh A: Program of Environmental Engineering and Climate Change (MAPEC), School of Engineering, The University of Jordan, Amman 11942, Jordan; Mechanical Engineering Department, School of Engineering, The University of Jordan, Amman 11942, Jordan
Sbeinati L: Hikma Pharmaceuticals, Amman 11118, Jordan
Saidan MN: Chemical Engineering Department, School of Engineering, The University of Jordan, Amman 11942, Jordan; Water, Energy and Environment Center, The University of Jordan, Amman 11942, Jordan
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Altalafha T: Program of Environmental Engineering and Climate Change (MAPEC), School of Engineering, The University of Jordan, Amman 11942, Jordan
Al-Naerat M: Program of Environmental Engineering and Climate Change (MAPEC), School of Engineering, The University of Jordan, Amman 11942, Jordan
Saidan H: The World Islamic Sciences and Education University, Finance and Management Faculty, Amman 11947, Jordan
Al-Salaymeh A: Program of Environmental Engineering and Climate Change (MAPEC), School of Engineering, The University of Jordan, Amman 11942, Jordan; Mechanical Engineering Department, School of Engineering, The University of Jordan, Amman 11942, Jordan
Sbeinati L: Hikma Pharmaceuticals, Amman 11118, Jordan
Saidan MN: Chemical Engineering Department, School of Engineering, The University of Jordan, Amman 11942, Jordan; Water, Energy and Environment Center, The University of Jordan, Amman 11942, Jordan
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Journal Name
Processes
Volume
6
Issue
2
Article Number
E15
Year
2018
Publication Date
2018-02-09
ISSN
2227-9717
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Original Submission
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PII: pr6020015, Publication Type: Journal Article
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LAPSE:2018.0305
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https://doi.org/10.3390/pr6020015
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Jul 31, 2018
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