LAPSE:2023.36033
Published Article
LAPSE:2023.36033
Lignocellulose-Derived Arabinose for Energy and Chemicals Synthesis through Microbial Cell Factories: A Review
June 7, 2023
Abstract
The exploration of natural substrates for microbial conversion to synthesize industrial platform and fuel chemicals seems to be inevitable within a circular bioeconomy context. Hemicellulose is a natural carbohydrate polymer consisting of a variety of pentose (C5) sugar monomers such as arabinose, mannose, erythrose, and xylose. Among the C5 sugars, L-arabinose (L-Ara) is the second-most-abundant pentose sugar in the lignocellulosic biomass after xylose. L-Ara has been used as an industrial carbon source to produce several value-added chemicals such as putrescine, which is used to synthesize polymers in the textile industry; sugar alcohols that are used as sweeteners in diet foods; and amino acids such as L-lysine, L-glutamate, L-arginine, and L-ornithine, which are used in nutritional supplements, fertilizers, and other products in the food and beverage industries. L-Ara, a natural non-caloric sweetener, is used as a substitute in the food and beverage industry, when the risk of blood sugar and lipid levels could be reduced. Major use of L-Ara is also found in the medical and pharmaceutical sectors to treat several conditions, including mineral absorption disorder, constipation, and diabetes, among others. In recent years, there has been a rising interest in synthesizing various sugar alcohols and derivatives, including arabitol, xylitol, and 2,3-butanediol, through the modification of producer organisms either genetically or metabolically to produce value-added products. Understanding the current demand and the need to increase the diversified production of industrial green chemicals with the reduced waste of useful lignocellulosic resources, this review focuses on the background of L-Ara and its various sources, microbes that utilize L-Ara to produce high-value-added products, and the future prospects for strain improvements to increase the yield of high-value-added products.
The exploration of natural substrates for microbial conversion to synthesize industrial platform and fuel chemicals seems to be inevitable within a circular bioeconomy context. Hemicellulose is a natural carbohydrate polymer consisting of a variety of pentose (C5) sugar monomers such as arabinose, mannose, erythrose, and xylose. Among the C5 sugars, L-arabinose (L-Ara) is the second-most-abundant pentose sugar in the lignocellulosic biomass after xylose. L-Ara has been used as an industrial carbon source to produce several value-added chemicals such as putrescine, which is used to synthesize polymers in the textile industry; sugar alcohols that are used as sweeteners in diet foods; and amino acids such as L-lysine, L-glutamate, L-arginine, and L-ornithine, which are used in nutritional supplements, fertilizers, and other products in the food and beverage industries. L-Ara, a natural non-caloric sweetener, is used as a substitute in the food and beverage industry, when the risk of blood sugar and lipid levels could be reduced. Major use of L-Ara is also found in the medical and pharmaceutical sectors to treat several conditions, including mineral absorption disorder, constipation, and diabetes, among others. In recent years, there has been a rising interest in synthesizing various sugar alcohols and derivatives, including arabitol, xylitol, and 2,3-butanediol, through the modification of producer organisms either genetically or metabolically to produce value-added products. Understanding the current demand and the need to increase the diversified production of industrial green chemicals with the reduced waste of useful lignocellulosic resources, this review focuses on the background of L-Ara and its various sources, microbes that utilize L-Ara to produce high-value-added products, and the future prospects for strain improvements to increase the yield of high-value-added products.
Record ID
Keywords
arabinose, hemicellulose, lignocellulosic biomass, metabolic engineering, value-added chemicals
Subject
Suggested Citation
Jacob S, Dilshani A, Rishivanthi S, Khaitan P, Vamsidhar A, Rajeswari G, Kumar V, Rajak RC, Din MFM, Zambare V. Lignocellulose-Derived Arabinose for Energy and Chemicals Synthesis through Microbial Cell Factories: A Review. (2023). LAPSE:2023.36033
Author Affiliations
Jacob S: Department of Biotechnology, School of Bioengineering, College of Engineering and Technology, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur 603203, India [ORCID]
Dilshani A: Department of Biotechnology, School of Bioengineering, College of Engineering and Technology, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur 603203, India
Rishivanthi S: Department of Biotechnology, School of Bioengineering, College of Engineering and Technology, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur 603203, India
Khaitan P: Department of Biotechnology, School of Bioengineering, College of Engineering and Technology, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur 603203, India
Vamsidhar A: Department of Biotechnology, School of Bioengineering, College of Engineering and Technology, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur 603203, India
Rajeswari G: Department of Biotechnology, School of Bioengineering, College of Engineering and Technology, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur 603203, India
Kumar V: School of Water, Energy and Environment, Cranfield University, Cranfield MK43 0AL, UK
Rajak RC: Department of Botany, Marwari College, Ranchi University, Ranchi 834008, India
Din MFM: Centre for Environmental Sustainability and Water Security (IPASA), Universiti Teknologi Malaysia, Bahru 81310, Malaysia; Department of Water and Environmental Engineering, School of Civil Engineering, Universiti Teknologi Malaysia, Bahru 81310, Malaysia
Zambare V: Centre for Environmental Sustainability and Water Security (IPASA), Universiti Teknologi Malaysia, Bahru 81310, Malaysia; R&D Department, Om Biotechnologies, Nashik 422011, India [ORCID]
Dilshani A: Department of Biotechnology, School of Bioengineering, College of Engineering and Technology, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur 603203, India
Rishivanthi S: Department of Biotechnology, School of Bioengineering, College of Engineering and Technology, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur 603203, India
Khaitan P: Department of Biotechnology, School of Bioengineering, College of Engineering and Technology, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur 603203, India
Vamsidhar A: Department of Biotechnology, School of Bioengineering, College of Engineering and Technology, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur 603203, India
Rajeswari G: Department of Biotechnology, School of Bioengineering, College of Engineering and Technology, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur 603203, India
Kumar V: School of Water, Energy and Environment, Cranfield University, Cranfield MK43 0AL, UK
Rajak RC: Department of Botany, Marwari College, Ranchi University, Ranchi 834008, India
Din MFM: Centre for Environmental Sustainability and Water Security (IPASA), Universiti Teknologi Malaysia, Bahru 81310, Malaysia; Department of Water and Environmental Engineering, School of Civil Engineering, Universiti Teknologi Malaysia, Bahru 81310, Malaysia
Zambare V: Centre for Environmental Sustainability and Water Security (IPASA), Universiti Teknologi Malaysia, Bahru 81310, Malaysia; R&D Department, Om Biotechnologies, Nashik 422011, India [ORCID]
Journal Name
Processes
Volume
11
Issue
5
First Page
1516
Year
2023
Publication Date
2023-05-16
ISSN
2227-9717
Version Comments
Original Submission
Other Meta
PII: pr11051516, Publication Type: Review
Record Map
Published Article
LAPSE:2023.36033
This Record
External Link
https://doi.org/10.3390/pr11051516
Publisher Version
Download
Meta
Record Statistics
Record Views
280
Version History
[v1] (Original Submission)
Jun 7, 2023
Verified by curator on
Jun 7, 2023
This Version Number
v1
Citations
Most Recent
This Version
URL Here
http://psecommunity.org/LAPSE:2023.36033
Record Owner
Calvin Tsay
Links to Related Works