The traditional manufacturing systems are often enterprise-centric systems, whereas the modern chemical industry is oriented towards industrial chain integration. Enterprise entities present a loosely coupled state at the scale of the industrial chain, with decentralized characteristics. This poses greater challenges and requirements for the industrial safety system. Based on the characteristics of the chemical manufacturing industry and blockchain, the application of the information security of blockchain in the chemical manufacturing industry is studied herein and the cyber-physical systems security architecture model of dual blockchains is proposed. The first-layer blockchain is applied at the system’s core function level to solve security issues at the system level and provide security guarantees for communication, transactions, and billing between users and manufacturers. Meanwhile, the second layer involves the system resource layer, which not only solves the security problem of cross-level platform data interaction, but also enables the point-to-point security of the device-level cyber-physical system to ensure internal equipment communication information security. A domestic commercial concrete manufacturing company’s real production and operation data were used to simulate basic functions such as transaction requests, trade success, and blockchain queries. After multiple tests, results show that its basic blockchain, query response, transaction creation, and block creation functions are all finished within milliseconds, meeting the industrial requirements. Its safety verification can meet the requirements of safety, efficiency, and low latency for production control in chemical industry sites, proving the feasibility of applying the dual blockchain model in the chemical manufacturing industry. Based on data security, privacy, and integrity requirements, the blockchain technology proposed in this article provides a more efficient, transparent, and secure operation and management solution for the chemical industry.