Previously conducted studies have established the conversion relationship between incident energy, reflected energy, transmitted energy and absorbed energy of rocks under dynamic load. In this paper, the combined dynamic and static loading tests of sandstone under different prestress and different bedding angles are carried out to explore the law of the influence of prestress and bedding angles on energy evolution and damage evolution. The purpose is to provide some reference for deep mining, rock engineering design and geological hazard assessment. The energy conversion and damage characteristics of sandstone in the whole process of deformation are studied, and the internal energy conversion mechanism of sandstone under dynamic load is proposed. It is found that the increase in prestress will lead to the increase in the initial energy value of sandstone and further affect the shape of the energy evolution curve. In addition, the relationship between strain and energy transformation is established, and it is found that the energy transformation in different stages is different. At the same time, the relationship between prestress and damage characteristics and bedding angle and damage characteristics is established, and it is found that bedding angle and prestress significantly affect the damage characteristics.